Guidelines and research
Official guidance for paediatric critical care, the evidence behind it, and the latest PICU research.
Open-access systematic reviews, meta-analyses and trials on PICU topics, chosen for relevance and how widely they are cited. Evidence informs guidance but doesn't replace it.
- Adherence to who severe acute malnutrition guidelines and mortality in critically ill children ‒ A cohort study in a pediatric intensive care unit.Research paperNutrición Hospitalaria (journal)2026Full text
- American Heart Association updated 2025 practice guidelines: Basic life support, advanced cardiovascular life support, pediatric advanced life support, and neonatal resuscitation.Review articleAmerican Heart Association2026
- Impact of the francophone pediatric intensive care group bronchiolitis recommendations on diagnostic testing, antibiotic therapy and patient prognosis.Research paperArchives de Pédiatrie (Société française de pédiatrie) – study of GFRUP guidelines2026
- Supporting clinical guidelines for opioid conversion to methadone and tapering to prevent withdrawal in critically ill children using physiology based pharmacokinetic modeling and simulation.Research paperPLoS One (Dutch Pediatric Formulary expert panel)2026Full text
- Admission Criteria to Paediatric Intensive Care for Oncology Haematology Patients: Updates and Evidence-Based Clinical Recommendations.Review articlePediatric Reports (review article)2026Full text
- From Consensus to Practice: Implementation and Impact of the Emergency Medicine Simulation Curriculum for Pediatrics (EM ReSCu Peds).Research paperCureus2026Full text
- Developing tailored dosing recommendations for ciprofloxacin in critically ill children using a population approach based on total and unbound concentrations.Research paperClinical Microbiology and Infection (ESCMID journal)2026
- Implementation of Polish guidelines on futile therapy protocols in pediatric intensive care units: a multicenter retrospective review.Research paperScientific Reports2026Full text
- Adherence to Sedation Protocol Recommendations in Intubated ICU Patients.Research paperPediatric Critical Care Medicine (SCCM/WFPICCS)2026
- Pediatric acute myocarditis: current evidence and practical recommendations.Review articleTrends in Cardiovascular Medicine2026Full text
- American Heart Association 2025 Guidelines: Basic life support, advanced cardiovascular life support, pediatric advanced life support, and neonatal resuscitation.Review articleAmerican Heart Association2026
- Report Cards as a Sustainability Tool for Guideline Adherence in Pediatric Traumatic Brain Injury.Research paperPediatric Quality & Safety (journal)2026
- Point-of-care ultrasound in nutrition assessment and enteral nutrition management of critically ill children: a scoping review.Review articleFrontiers in Nutrition2026Full text
- Association between enteral feeding guideline implementation and early enteral nutrition in children with critical bronchiolitis: An uncontrolled before-after study.Research paperJPEN (Journal of Parenteral and Enteral Nutrition)2026
- Is There Any Dose of Benzodiazepines Safe for Delirium in the PICU? A Secondary Analysis of the PICU Up! Pilot Trial Dataset.Research paperCritical Care Explorations (PICU Up! trial investigators)2026Full text
- A Core Outcome Set for Family-Centered Care in Neonatal Intensive Care Settings: An International eDelphi Study and Online Consensus Meeting.Research paperChildren (Basel)2026Full text
- Pediatric Intensive Care Core Outcomes-a modified Delphi consensus process (PIC-CO).OtherGerman Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI) – Section of Paediatric Intensive Care and Emergency Medicine (SPIE)2026Full text
- Tranexamic acid and beyond: A systematic review of pediatric post-tonsillectomy hemorrhage protocols and introduction of a universal management guideline.Review articleInternational Journal of Pediatric Otorhinolaryngology2026Full text
- Impact of genomic sequencing information on physicians' treatment recommendations for children with congenital heart disease.Research paperGenetics in Medicine Open2025Full text
- Rethinking Pediatric Sepsis and Septic Shock: Beyond International Consensus Criteria.CommentaryPediatric Health, Medicine and Therapeutics (expert commentary)2025Full text
- Prospective Evaluation of Adherence to French Guidelines on Early Onset Sepsis Management.Research paperThe Pediatric Infectious Disease Journal2025
- High-flow nasal cannula oxygen therapy for children with bronchiolitis: Implementation of a national guideline.Research paperActa Paediatrica2025Full text
- CPR coach presence is associated with increased cardiopulmonary resuscitation guideline adherence in pediatric in-hospital cardiac arrest: a retrospective cohort study.Research paperResuscitation (journal)2025Full text
- Individualised amoxicillin-clavulanate dosing recommendations for critically ill children with augmented clearance after cardiac surgery.Research paperInternational Journal of Antimicrobial Agents2025
- Pediatric Acute Respiratory Distress Syndrome Updates in the Light of the PALICC-2 Guidelines.Review articleTurkish Archives of Pediatrics2025Full text
- A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up - towards an international prognostication guideline.Research paperResuscitation Plus (PROGNOSE registry, Netherlands)2025Full text
- Association Between Adherence to Guidelines and Patient Outcomes in Severe Pediatric Traumatic Brain Injury: A Scoping Review.Review articleJournal of Neurotrauma2025
- Prearrest vital sign abnormalities are associated with adverse outcomes in pediatric ICU cardiac arrest: a get with the guidelines-resuscitation analysis.Research paperResuscitation (American Heart Association Get With The Guidelines-Resuscitation registry study)2025Full text
- A Frostbite Treatment Guideline for Pediatric Patients.Research paperJournal of Burn Care & Research (American Burn Association) - single-institution consensus2025
- What is the New Research in Pediatric Critical Illness-Related Delirium Since the 2022 Clinical Practice Guidelines.Review articlePediatric Critical Care Medicine (SCCM/WFPICCS journal)2025
- Futile therapy protocols: A 3-year review of the implementation of Polish guidelines on ineffective organ function maintenance in pediatric intensive care unit-A pilot study.Research paperBMC Palliative Care2025Full text
- Survey of Pediatric Status Epilepticus Treatment Practices and Adherence to Management Guidelines (Pedi-SPECTRUM e-Survey).Research paperIndian Journal of Critical Care Medicine (Indian Society of Critical Care Medicine)2024Full text
- Measuring evidence-based clinical guideline compliance in the paediatric intensive care unit.Research paperBMJ Open Quality2024Full text
- Clinical guideline highlights for the hospitalist: International consensus criteria for pediatric sepsis and septic shock.Review articleSociety of Critical Care Medicine (Phoenix criteria)2024Full text
- Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.OtherPediatric ECMO Anticoagulation CollaborativE (PEACE) / Society of Critical Care Medicine2024Full text
- Phenotypes based on respiratory drive and effort to identify the risk factors when P0.1 fails to estimate ∆PES in ventilated children.Research paperCritical Care (BioMed Central)2024Full text
- Implementation of the American Society of Anesthesiologists 2022 paediatric guidelines in a child with mandibular metastasis.OtherAnaesthesia Reports (case report applying ASA 2022 difficult airway guidelines)2024Full text
- Perceived family-centered care and post-traumatic stress in parents of infants cared for in the paediatric cardiac intensive care unit.Research paperNursing in Critical Care2024Full text
- The perinatal period should be considered in neonatal acute respiratory distress syndrome: comparison of the Montreux definition vs. the second pediatric acute lung injury consensus conference definition.Research paperFrontiers in Pediatrics2023Full text
- Implementing Pediatric Surviving Sepsis Campaign Guidelines: Improving Compliance With Lactate Measurement in the PICU.Research paperCritical Care Explorations2023Full text
- Estimation of inspiratory effort using airway occlusion maneuvers in ventilated children: a secondary analysis of an ongoing randomized trial testing a lung and diaphragm protective ventilation strategy.Research paperCritical Care (BioMed Central)2023Full text
- Cognitive function following diabetic ketoacidosis in young children with type 1 diabetes.Research paperEndocrinology, Diabetes & Metabolism (journal)2023Full text
- Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.Research paperJAMA Network Open2022Full text
- Is prehospital intubation of severely injured children in accordance with guidelines?Research paperBMC Emergency Medicine (TraumaRegister DGU)2022Full text
- Evidence-based practical guideline for procedural pain management and sedation for burn pediatrics patients undergoing wound care procedures.Review articleAnnals of Medicine and Surgery2022Full text
- A Survey of Hospital Pharmacy Guidelines for the Administration of 3% Sodium Chloride in Children.Research paperChildren (Basel) / Children's Hospital Association survey2022Full text
- School and Work Absences After Critical Care Hospitalization for Pediatric Acute Respiratory Failure: A Secondary Analysis of a Cluster Randomized Trial.Research paperJAMA Network Open2021Full text
- Development and Implementation of Pediatric ICU-based Mobility Guidelines: A Quality Improvement Initiative.Research paperPediatric Quality & Safety (journal)2021Full text
- Trends Over Time in Use of Nonrecommended Tests and Treatments Since Publication of the American Academy of Pediatrics Bronchiolitis Guideline.Research paperJAMA Network Open2021Full text
- Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.Research paperCritical Care (BioMed Central)2021Full text
- Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit.Research paperCritical Care (PEPaNIC investigators)2020Over 5 years oldFull text
- Clinical practice guideline on the prevention and management of neonatal extravasation injury: a before-and-after study design.Research paperBMC Pediatrics2020Over 5 years oldFull text
- Clinical guidelines on pediatric asthma exacerbation in emergency department, a narrative review.Review articleEuropean Journal of Translational Myology2020Over 5 years oldFull text
- Association of guideline publication and delays to treatment in pediatric status epilepticus.Research paperNeurology (pSERG)2020Over 5 years oldFull text
- [Interpretation on the "surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children"].Review articleChinese Journal of Contemporary Pediatrics2020Over 5 years old
- 1142. Implementation and Impact of a Tracheitis Diagnosis and Management Guideline in a Pediatric Intensive Care UnitResearch paperOpen Forum Infectious Diseases (IDWeek abstract)2019Over 5 years oldFull text
- Commentary: Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.CommentaryBrain Trauma Foundation2019Over 5 years old
- Commentary: Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.CommentaryBrain Trauma Foundation2019Over 5 years old
- Restrictive guideline for red blood cell transfusions in preterm neonates: effect of a protocol change.Research paperVox Sanguinis2019Over 5 years oldFull text
- Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies.Research paperJournal of Antimicrobial Chemotherapy2018Over 5 years oldFull text