Individualised amoxicillin-clavulanate dosing recommendations for critically ill children with augmented clearance after cardiac surgery.

Summary

A population pharmacokinetic study of amoxicillin-clavulanate in critically ill children after cardiac surgery, using blood sampling and NONMEM modelling with allometric and maturation scaling. Clearance was markedly augmented except in those receiving vasopressors, in whom clearance was reduced. Simulations suggested more frequent dosing may be needed to attain the pharmacokinetic/pharmacodynamic target in children not on vasopressors. Useful background for PICU clinicians on antibiotic exposure variability after cardiac surgery, though it is a research study rather than a formal guideline.

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