Evidence · Research paper
Is There Any Dose of Benzodiazepines Safe for Delirium in the PICU? A Secondary Analysis of the PICU Up! Pilot Trial Dataset.
- Delirium
- Early mobilisation
- Medical
- Neurology
- Nursing
- Sedation
- Sedation and analgesia
Summary
A secondary analysis of over 10,000 patient-days from the multicentre PICU Up! pilot randomised trial examining the dose-response relationship between sedative exposure and next-day delirium in critically ill children. Higher previous-day benzodiazepine dose was associated with increased odds of delirium, with the steepest rise at the lowest doses and no safe threshold identified. Any dexmedetomidine exposure and same-day physical restraint use were also associated with increased delirium odds, while opioid dose was not. Supports minimising benzodiazepine use and individualised sedation and restraint practices in PICU.
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- Licence:
- Open (Creative Commons)
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