Evidence · Systematic review or meta-analysis
SEVERE PERTUSSIS IN CHILDHOOD: UPDATE AND CONTROVERSY - SYSTEMATIC REVIEW.
- Blood products
- Haematology and oncology
- Infection and sepsis
- Mechanical ventilation
- Medical
- Nursing
- Respiratory
- Sepsis
- Shock
This paper is from 2019, more than five years ago. Newer evidence may have been published since.
Summary
Systematic review of severe (malignant) pertussis in infants and children, covering epidemiology of this re-emerging disease, pathophysiology, clinical features, antibiotic therapy and adjunctive treatments. It highlights that the most severe disease occurs in neonates and young infants, with hyperleucocytosis, respiratory failure, pulmonary hypertension-related shock and secondary infections. Macrolides remain the antibiotics of choice while antitussives lack efficacy; early intensive care improves outcome and leucoreduction by exchange transfusion is described as promising but unproven. Relevant to PICU teams managing critically ill infants with pertussis.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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