Evidence · Systematic review or meta-analysis
Combination of ipratropium bromide and salbutamol in children and adolescents with asthma: A meta-analysis.
- Asthma
- Medical
- Nursing
- Respiratory
Summary
Meta-analysis of 55 randomised trials (6396 children and adolescents ≤18 years) comparing inhaled ipratropium bromide plus salbutamol with salbutamol alone for acute asthma. The combination was associated with a reduced risk of hospital admission, with the effect most apparent in moderate-to-severe and severe exacerbations, and no significant difference in adverse events. Evidence quality varied from very low to high, and the authors call for larger well-designed double-blind trials. Relevant to clinicians managing acute paediatric asthma in emergency and critical care settings.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to PICUlearn members, and Peeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.