Evidence · Randomised trial
FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care.
- Mechanical ventilation
- Medical
- Non-invasive ventilation and high flow
- Nursing
- Physiotherapy
- Respiratory
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
A multicentre pilot randomised controlled trial comparing high-flow nasal cannula therapy with CPAP as first-line non-invasive respiratory support in critically ill children, in both step-up and step-down groups. It primarily assessed feasibility: eligibility, randomisation and consent rates, and adherence to treatment algorithms, with research-without-prior-consent used in emergencies. Secondary data included adverse events, treatment crossover, intubation within 72 hours and ventilator-free days. The authors concluded a large national RCT is feasible after refinements to consent procedures and algorithms.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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