Evidence · Systematic review or meta-analysis
Clinical characteristics of severe neonatal enterovirus infection: a systematic review.
- Blood products
- Cardiovascular
- ECMO
- Infection and sepsis
- Mechanical ventilation
- Medical
- Meningitis and encephalitis
- Nursing
- Respiratory
- Sepsis
Summary
A systematic review of 66 publications describing 237 neonates with severe enterovirus infection. It summarises presenting features (temperature abnormality, rash, poor feeding, respiratory symptoms), complications such as hepatitis/coagulopathy, myocarditis and meningoencephalitis, and reported mortality, highest in those with myocarditis. Supportive management described included blood component transfusion, mechanical ventilation and ECMO, with widespread empirical antibiotics and IVIG, and limited antiviral experience. Useful background for intensivists caring for critically unwell neonates with suspected viral sepsis.
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- Licence:
- Open (Creative Commons)
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