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Evidence · Systematic review or meta-analysis

The role of viral co-infections in the severity of acute respiratory infections among children infected with respiratory syncytial virus (RSV): A systematic review and meta-analysis.

Systematic review or meta-analysisJournal of Global Health2020Over 5 years oldFull text
  • Bronchiolitis
  • Infection and sepsis
  • Mechanical ventilation
  • Medical
  • Nursing
  • Respiratory

This paper is from 2020, more than five years ago. Newer evidence may have been published since.

Summary

A systematic review and meta-analysis comparing clinical severity between RSV mono-infection and RSV viral co-infection in children under five with acute respiratory infection. Overall, co-infection with other respiratory viruses was not associated with greater severity, with the exception of RSV-human metapneumovirus co-infection, which was linked to higher odds of ICU admission and possibly longer hospital stay. Relevant to PICU staff interpreting viral PCR panels in infants admitted with bronchiolitis or viral pneumonia.

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