Evidence · Randomised trial
Early resuscitation of dengue shock syndrome in children with hyperosmolar sodium-lactate: a randomized single-blind clinical trial of efficacy and safety.
- Cardiac arrest and resuscitation
- Cardiovascular
- Fluids and electrolytes
- Infection and sepsis
- Medical
- Nursing
- Renal and metabolic
- Shock
This paper is from 2014, more than five years ago. Newer evidence may have been published since.
Summary
A single-blind randomised trial in 50 Indonesian children with dengue shock syndrome comparing WHO-recommended Ringer's lactate resuscitation with a smaller-volume hypertonic sodium-lactate solution. Haemodynamic recovery, plasma expansion, clinical outcome and survival were similar between groups, while fluid accumulation was lower with hypertonic sodium lactate and endothelial marker sVCAM-1 fell. Relevant to PICU teams managing fluid-refractory shock and concerns about fluid overload, particularly in dengue-endemic settings.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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