Guideline · Consensus statement
Surfactant therapies for pediatric and neonatal ARDS: ESPNIC expert consensus opinion for future research steps.
- Mechanical ventilation
- Medical
- Nursing
- PARDS
- Respiratory
Summary
An ESPNIC expert consensus reviewing preclinical and clinical evidence on surfactant therapy for paediatric (PARDS) and neonatal (NARDS) ARDS. It notes that prior trials pre-dated current definitions and were heterogeneous in patient characteristics, surfactant type and administration strategy, with inconsistent effects on oxygenation and mortality. Four consensus statements advocate targeted research using current definitions, treating PARDS and NARDS as distinct syndromes characterised by direct/indirect nature, severity, infectious origin and age, favouring explanatory trial designs and outcome measures tailored to each population. Aimed at clinicians and researchers in paediatric and neonatal critical care to guide future study design.
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- Open (Creative Commons)
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