Guideline
ASH/ISTH 2026 guidelines for anticoagulant prophylaxis in pediatric patients at risk of venous thromboembolism.
- Blood products
- Care and rehabilitation
- Gastrointestinal and nutrition
- Haematology and oncology
- Line and device care
- Major trauma
- Medical
- Nursing
- Nutrition
- Oncology emergencies
- Trauma and burns
Summary
Evidence-based ASH/ISTH guidelines on anticoagulant prophylaxis to prevent venous thromboembolism in children, developed by a multidisciplinary GRADE panel with systematic evidence review to April 2025. Twelve largely conditional recommendations cover subgroups including critically ill children, trauma patients, solid cancer, acute lymphoblastic leukaemia or lymphoma, surgical and hospitalised patients, central venous access devices, antiphospholipid antibody syndrome and long-term parenteral nutrition. The panel suggests against prophylaxis in some groups and in favour in others, reflecting very limited high-quality paediatric data. Research priorities include validated subgroup-specific risk assessment models and trials of risk-stratified prophylaxis.
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