Evidence · Systematic review or meta-analysis
Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review.
- Acute liver failure
- Gastrointestinal and nutrition
- Medical
- Renal and metabolic
- Renal replacement therapy
Summary
A systematic review of treatments for paediatric drug-induced liver injury, including acetaminophen overdose and idiosyncratic DILI. It summarises 25 publications covering 140 children from preterm neonates to adolescents, with therapies including N-acetylcysteine, corticosteroids, carnitine, ursodeoxycholic acid and extracorporeal liver support or continuous renal replacement therapy. The authors conclude the evidence is low quality and largely extrapolated from adults, highlighting a need for paediatric-specific studies. Relevant to PICU teams managing acute liver failure and poisoning.
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- Licence:
- Open (Creative Commons)
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