Evidence · Randomised trial
Management of Ventilator-Associated Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center: A Randomized Controlled Study.
- Infection and sepsis
- Infection prevention
- Mechanical ventilation
- Medical
- Nursing
- Respiratory
- Sepsis
Summary
A randomised controlled study from a PICU at Cairo University Hospital examining empirical antibiotic strategies for ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii in children aged one month to twelve years ventilated for more than 48 hours. Susceptibility was assessed using minimal inhibitory concentration testing and a double antibiotic synergism test, with clinical responses compared between monotherapy and combination regimens. The authors report greater improvement with multi-agent combinations and note that polymyxin use requires careful stewardship to limit further resistance. Optimal treatment duration remains uncertain, though courses beyond a week were generally needed for eradication.
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- Open (Creative Commons)
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