Evidence · Randomised trial
REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: a pilot randomized controlled trial (REDUCE-1).
- Fluids and electrolytes
- Mechanical ventilation
- Medical
- Nursing
- Renal and metabolic
- Renal replacement therapy
- Respiratory
Summary
A pilot, open-label randomised controlled trial across three PICUs in Australia and Switzerland testing a restrictive IV fluid strategy versus usual care for 48 hours in invasively ventilated children under 18. The restrictive arm involved lower maintenance fluid, smaller boluses, less drug dilution and earlier diuretics or peritoneal dialysis. Recruitment fell short of targets and fluid balance separation between arms was minimal, so the protocol was judged not feasible for a full trial as designed. Relevant to PICU teams interested in fluid overload prevention and trial design, with the authors suggesting stricter intervention guidance or bundled care in future studies.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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