Evidence · Randomised trial
The Infant KIdney Dialysis and Utrafiltration (I-KID) Study: A Stepped-Wedge Cluster-Randomized Study in Infants, Comparing Peritoneal Dialysis, Continuous Venovenous Hemofiltration, and Newcastle Infant Dialysis Ultrafiltration System, a Novel Infant Hemodialysis Device.
- Acute kidney injury
- Fluids and electrolytes
- Medical
- Nursing
- Renal and metabolic
- Renal replacement therapy
Summary
A UK stepped-wedge cluster-randomised trial across six PICUs comparing a novel infant haemodialysis device (NIDUS) with peritoneal dialysis and CVVH in babies under 8 kg requiring renal replacement therapy for fluid overload or biochemical disturbance. The primary outcome was precision of ultrafiltration against prescription, with secondary outcomes of biochemical clearance, clinical efficacy and safety. NIDUS achieved ultrafiltration closer to prescription than controls, with creatinine clearance intermediate between PD and CVVH; adverse events occurred in all groups and mortality varied by modality in this multi-organ failure population. Relevant to PICU teams managing small infants needing RRT, highlighting device options and trade-offs between fluid control and clearance.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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