Evidence · Randomised trial
A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis.
- Fluids and electrolytes
- Gastrointestinal and nutrition
- Medical
- Nursing
- Renal and metabolic
This paper is from 2016, more than five years ago. Newer evidence may have been published since.
Summary
A double-blind randomised trial across eight North American paediatric emergency departments comparing balanced crystalloid (Plasma-Lyte A) with 0.9% sodium chloride for intravenous rehydration in children with moderate to severe dehydration from acute gastroenteritis. The primary outcome was serum bicarbonate at four hours, with safety and tolerability as secondary outcomes. Balanced fluid was associated with more rapid improvement in bicarbonate and dehydration score, with similar fluid volumes, admission rates and no clinically relevant safety concerns. Relevant to PICU staff considering balanced versus saline resuscitation fluids in dehydrated children, though the setting is emergency rather than intensive care.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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