Evidence · Randomised trial
SABRE: a multicentre randomised control trial of nebulised hypertonic saline in infants hospitalised with acute bronchiolitis.
- Bronchiolitis
- Medical
- Nursing
- Physiotherapy
- Respiratory
This paper is from 2014, more than five years ago. Newer evidence may have been published since.
Summary
Pragmatic open multicentre UK randomised controlled trial of 6-hourly nebulised 3% hypertonic saline added to usual care in 317 infants hospitalised with acute bronchiolitis and requiring oxygen. The primary outcome was time to being assessed as fit for discharge, with secondary outcomes of actual discharge time, adverse events and 28-day follow-up. No difference was found between hypertonic saline and standard care for any outcome, and adverse events were similar. The authors conclude the findings do not support routine use of nebulised hypertonic saline in acute bronchiolitis.
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- Licence:
- Open (Creative Commons)
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