Evidence · Systematic review or meta-analysis
Association of Extubation Failure Rates With High-Flow Nasal Cannula, Continuous Positive Airway Pressure, and Bilevel Positive Airway Pressure vs Conventional Oxygen Therapy in Infants and Young Children: A Systematic Review and Network Meta-Analysis.
- Airway
- Intubation
- Mechanical ventilation
- Medical
- Non-invasive ventilation and high flow
- Nursing
- Physiotherapy
- Respiratory
Summary
A systematic review and bayesian network meta-analysis of 9 randomised trials (1421 children) comparing post-extubation noninvasive respiratory support — high-flow nasal cannula, CPAP and BiPAP — with conventional oxygen therapy in critically ill infants and young children ventilated for more than 24 hours. Outcomes included extubation failure, treatment failure, PICU mortality, length of stay, abdominal distension and nasal injury. CPAP and HFNC were associated with lower extubation and treatment failure than conventional oxygen, with CPAP ranked highest, while CPAP and BiPAP were associated with modest increases in nasal injury and abdominal distension. Directly informs PICU extubation and weaning practice.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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