Evidence · Systematic review or meta-analysis
Accuracy of cystatin C in prediction of acute kidney injury in children; serum or urine levels: which one works better? A systematic review and meta-analysis.
- Acute kidney injury
- Medical
- Renal and metabolic
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
This systematic review and meta-analysis pooled 24 studies (nearly 2000 children) comparing serum and urinary cystatin C as predictive biomarkers for acute kidney injury. Analyses were stratified by sample type and reported standardised mean differences and prognostic performance characteristics. The authors conclude cystatin C has acceptable prognostic value for paediatric AKI, with serum levels rising early after admission. Relevant to PICU clinicians considering early biomarkers for AKI detection alongside traditional measures.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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