Evidence · Randomised trial
Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.
- Mechanical ventilation
- Medical
- Non-invasive ventilation and high flow
- Nursing
- Respiratory
Summary
Report of the COAST fractional-factorial randomised trial in Ugandan and Kenyan children over 28 days old with severe pneumonia, comparing high-flow nasal therapy, low-flow oxygen and a permissive hypoxaemia strategy across severe hypoxaemia and hypoxaemia strata. The primary outcome was 48-hour mortality, with mortality or neurocognitive sequelae at 28 days as secondary outcomes; the trial stopped early after enrolling 1852 of a planned 4200 children. Findings suggested potential benefit of high-flow nasal therapy and the authors call for further trials. Directly relevant to PICU teams delivering oxygen and non-invasive respiratory support, particularly in resource-limited settings.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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