Evidence · Randomised trial
A Mixed Lipid Emulsion for Prevention of Parenteral Nutrition Associated Cholestasis in Extremely Low Birth Weight Infants: A Randomized Clinical Trial.
- Acute liver failure
- Gastrointestinal and nutrition
- Medical
- Nursing
- Nutrition
This paper is from 2018, more than five years ago. Newer evidence may have been published since.
Summary
A double-blind randomised controlled trial in a single level IV neonatal unit comparing a mixed lipid emulsion (soybean oil, MCT, olive oil, fish oil) with a soybean oil-based emulsion for parenteral nutrition in 230 extremely low birth weight infants. The primary outcome was parenteral nutrition associated cholestasis defined by consecutive raised conjugated bilirubin measurements. No statistically significant reduction in cholestasis or other neonatal morbidity was found with the mixed lipid emulsion. Of interest to PICU and neonatal teams managing long-term parenteral nutrition and hepatic complications.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
The full text of this openly licensed paper is available to PICUlearn members, and Peeky can answer questions from it.
Guidelines are shown for education. Follow your unit's own guidance and senior advice.