Evidence · Systematic review or meta-analysis
Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis.
- Mechanical ventilation
- Medical
- Nursing
- Respiratory
- Sedation
- Sedation and analgesia
Summary
Systematic review and meta-analysis of 6 randomised trials (2810 children) comparing daily sedation interruption with continuous intravenous sedation in ventilated PICU patients. Daily interruption was associated with a shorter PICU stay, with no significant difference in duration of mechanical ventilation, cumulative midazolam or morphine doses, adverse events or mortality. Relevant to PICU teams designing sedation protocols and weaning practice. The authors call for further work on neurodevelopmental outcomes in survivors.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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