Evidence · Randomised trial
The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial.
- Acute kidney injury
- Cardiovascular
- Congenital heart disease
- Medical
- Renal and metabolic
- Sedation
- Sedation and analgesia
This paper is from 2017, more than five years ago. Newer evidence may have been published since.
Summary
A small single-centre randomised trial in 29 children aged 1-6 years undergoing septal defect repair, comparing intraoperative dexmedetomidine infusion with saline. Outcomes were serum creatinine, estimated GFR and renal biomarkers through to the second postoperative day, with AKI defined by creatinine rise. The dexmedetomidine group had a lower incidence of perioperative AKI and less post-bypass decline in eGFR. Relevant to PICU teams managing children after cardiac surgery, though the sample size is small and findings are preliminary.
Summary written for PICUlearn. Always read the original.
- Licence:
- Open (Creative Commons)
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