Evidence · Systematic review or meta-analysis
A systematic review of dexmedetomidine pharmacology in pediatric patients.
- Medical
- Nursing
- Sedation
- Sedation and analgesia
Summary
A systematic review of dexmedetomidine pharmacokinetics, pharmacodynamics and pharmacogenomics in children, including neonatal and paediatric intensive care use. It notes that age and size are the strongest predictors of dexmedetomidine disposition, and reviews candidate pharmacogenes with generally weak individual evidence for altered response. Relevant to PICU clinicians titrating dexmedetomidine for procedural sedation and during mechanical ventilation, where over- or under-sedation risks bradycardia, hypotension or self-extubation. The authors highlight the need for individualised paediatric dosing strategies.
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- Licence:
- Open (Creative Commons)
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