Evidence · Systematic review or meta-analysis
Association of Arterial Hyperoxia With Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis.
- Cardiac arrest and resuscitation
- Cardiovascular
- ECMO
- Mechanical ventilation
- Medical
- Neurology
- Nursing
- Respiratory
- Traumatic brain injury
Summary
Systematic review and meta-analysis of 16 studies (over 27 000 children) examining the association between arterial hyperoxia and outcomes in paediatric intensive care. Populations included post-cardiac arrest, traumatic brain injury, ECMO and general PICU cohorts, with widely varying definitions of hyperoxia based mainly on categorical PaO2 cut-offs. Pooled analysis suggested hyperoxia was associated with increased mortality, with substantial between-study heterogeneity and a signal of harm at higher oxygen thresholds. The authors highlight methodological limitations and the need for prospective studies to guide oxygen targeting in critically ill children.
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- Open (Creative Commons)
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